Description
Key ingredients:
- All-trans Retinol: the most potent OTC retinoid form, used here at a more advanced concentration than the Gentle Retinol serum
- Patent-Approved Active Pro-Penetrant Delivery System: ensures retinol reaches the target depth in the skin where it can do its most meaningful work
- Bakuchiol: a natural ingredient derived from the Psoralea corylifolia seed with retinol-like gene expression activity. Reduces redness and boosts antioxidant protection alongside the retinol rather than competing with it.
- Licorice Root: anti-inflammatory pigment control that brightens while the retinol resurfaces
- Green Tea Polyphenols: antioxidant and calming support throughout the retinization process
How to use:
Apply one full pipette to clean, dry skin at night only. Begin every third night for the first two weeks, then every other night for the next two weeks, then every night as tolerated. Do not apply to wet skin. Follow immediately with the Lipid Replenishing Soft Cream. Always use SPF during the day. This serum is intended for patients who have already built tolerance on the Gentle Retinol or an equivalent retinol product.
Good to know:
✓ Fragrance free ✓ Oil free ✓ Gluten free ✓ Paraben free ✓ Patent-approved delivery system ✓ Published in the Journal of Drugs in Dermatology ✓ Clinically studied against prescription tretinoin: equivalent or better results ✓ Available in 2.5x and 5x strengths ✓ Physician-curated ✓ Step 5 of your routine (after moisturizer, last step at night)
Some dryness, redness, or flaking during the first few weeks is completely normal and expected. It is a sign your skin is retinizing. The remedy is simple: use our Lipid Replenishing Soft Cream on top every night. It was the moisturizer used alongside this exact serum in the clinical study.
This is the retinol that was studied head-to-head against prescription tretinoin in a published peer-reviewed clinical trial and came out equivalent or better. If you have ever been told you need a prescription retinoid, this is worth knowing about. Once you have been consistently tolerating the 5x strength, Dr. Milman will check in with you at your next visit to discuss whether any further escalation makes sense for your skin.

